APSC 480 - Directed Research in Medical Chemistry and Structural Biology

Fall or Spring (3) (College 400)

A new interdisciplinary capstone course designed to encompass concepts and methods from biology, chemistry, and physics, and investigate structure-function relationships of novel bioactive marine compounds. Macromolecular compounds essential for the immunity of fish species living in the Chesapeake Bay will be featured in research projects designed by students. The process will involve learning relevant concepts in medicinal chemistry and structural biology, and bringing to biochemical and biophysical analysis host-defense compounds that target cellular components of pathogens, such as cell membranes and nucleic acids. The projects will be designed to highlight biochemical and biophysical concepts that are fundamental to structure-function relationships and will provide training in scientific methods such as purification of active compounds, reconstitution under native-like conditions, and quantitative analysis of functional and structural properties. Specific methods will include liquid chromatography, circular dichroism, high-resolution solid-state nuclear magnetic resonance. Students will also broaden the scope of their projects by considering the ramifications of their research on our local society. Connections to issues related to the fishing industry, environmental quality, the impact of human activities on marine habitats, and coastal policy will be encouraged.