MSCI 583 - Molecular Genetic Data Analysis, Bioinformatics

Spring, odd years 3 Reece.

This is a lecture and largely computer-based laboratory course covering the principles and practice of analyzing and interpreting population genetic, phylogenetic and genetic mapping datasets. Molecular data sets including sequences and genotypic profiles will be generated on agarose gels or the automated sequencers/ gel scanners. Data will be exported and processed for analysis by the appropriate suite of computer software programs. Software to be utilized include DNA sequence analysis, genotyping, population genetic, sequence alignment, phylogenetic, and mapping programs. Phylogenetic programs will include those based on genetic distance, maximum parsimony, maximum likelihood and Bayesian analyses. Population genetics programs include those such as GenePop to perform standard population genetic statistical analyses, Arlequin for doing AMOVAs, and STRUCTURE for doing assignment testing.