BIOL 546 - Nuclear Structure and Gene Activity

Spring (3) Allison. Prerequisite(s): BIOL 442, or permission of instructor.

An in-depth advanced exploration of the structure of the nucleus and molecular mechanisms of eukaryotic gene regulation, based on readings from the current primary literature. Topics will include mechanisms regulating nuclear import and export of transcription factors and RNA, the role nuclear architecture plays in gene activity and RNA processing, and how failure to appropriately coordinate these processes leads to abnormal or diseased states. Three class hours.